Uusi opinto-opas (sisältäen myös opetusohjelmat) lukuvuodelle 2018-2019 sijaitsee osoitteessa https://opas.peppi.utu.fi . Tältä sivustolta löytyvät enää vanhat opinto-oppaat ja opetusohjelmat.

The new study guide (incl. teaching schedules) for academic year 2018-2019 can be found at https://studyguide.utu.fi. This site contains only previous years' guides.

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Arkistoitu opetussuunnitelma 2014–2016
Selaamasi opetussuunnitelma ei ole enää voimassa. Tarkista tiedot voimassa olevasta opetussuunnitelmasta.
KEMI4152 Chemistry and chemical biology of nucleic acids 3 op
Organised by
Chemistry
Person in charge
Harri Lönnberg

Learning outcomes

Life in all its forms is based on nucleic acids which store and transfer genetic information and catalyze some fundamental cellular processes, including protein synthesis and tailoring of nucleic acids. Accordingly, nucleic acids have received increasing interest as a target of chemotherapy and oligonucleotides as chemotherapeutic agents. This lecture course is aimed at elucidating the central role of chemistry in the rapid developing field of nucleic acid cell biology. Attention is paid to synthesis of structurally modified biomolecules and their conjugates useful as research tool for cell biology and understanding of the chemical basis of biological phenomena at the level of individual bond making and breaking processes and interatomic interactions.

Contents

Protolytic equilibria, conformations, tautomerism and coordination chemistry of nucleosides and nucleotides. Structure and reactivity of nucleic acids. Basic principles of phosphorus chemistry. Catalytic nucleic acids. Synthesis of nucleosides, nucleotides and oligonucleotides, their structural analogs and conjugates useful in chemotherapy or research tools for cell biology. Therapeutic oligonucleotides. Pro-drug strategies of nucleotide drugs.

Teaching language

English

Modes of study

Option 1
Available for:
  • Degree Programme Students
  • Other Students
  • Doctoral Students
  • Exchange Students
Participation in classroom work
  • In English

Weekly tasks.

Evaluation

Numeric 0-5.

Study materials

Lecture notes in Moodle.

Further information

Course will be lectured fall 2015.

Belongs to following study modules

Kemian laitos
2014–2015
Teaching
Archived Teaching Schedule. Please refer to current Teaching Shedule.
Implementation details are unavailable.
Kemian laitos
Opintokokonaisuudet