Curricula Guides

Uusi opinto-opas (sisältäen myös opetusohjelmat) lukuvuodelle 2018-2019 sijaitsee osoitteessa https://opas.peppi.utu.fi . Tältä sivustolta löytyvät enää vanhat opinto-oppaat ja opetusohjelmat.

The new study guide (incl. teaching schedules) for academic year 2018-2019 can be found at https://studyguide.utu.fi. This site contains only previous years' guides.

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Archived Curricula Guide 2016–2018
Curricula Guide is archieved. Please refer to current Curricula Guides
DRUG0005 Principles of Drug Discovery and Development 8 ECTS
Organised by
Drug Discovery and Development
Person in charge
Markku Koulu

Learning outcomes

The aim of the study module is that students can describe the purpose of the different phases of the drug discovery and development process and discuss which particular aspects are emphasized at each stage. Students can critically evaluate and select appropriate research methods to elucidate the pharmacological and pharmaceutical properties of drug molecules as well as to assess the toxicological and safety profiles of drug candidates during the various stages of non-clinical and clinical drug development. Furthermore, students should demonstrate that they understand differences that exist between "conventional" small molecule drugs and biotechnologically produced biological drugs in terms of their chemical, biological and pharmacological properties that give rise to to rather different drug development processes. In addition, students should be able to explain the role of intellectual property rights (IPR) in drug development and how this is reflected in the strategies of drug companies. Students should also become familiar with the ethical guidelines that regulate the use of laboratory animals in research and clinical investigations carried out in humans. Students will also be able to critically assess some historical cases of drug development and to compare these with contemporary cases in order to obtain a wider perspective of the progress that has taken place in drug development science. As built-in component, students practice communication skills by preparing scientific presentations for seminars and writing lab work report.

Contents

This study module consists of topics divided into the following areas: a) general introduction to the principles of drug discovery and development (historical perspectives and future trends in drug discovery and development, general role of drugs in health care and society, the roles of academia and drug companies in the different phases of drug development, regulatory aspects in drug development), b) drug discovery (identification of biological targets and their validation, screening assay development, high-throughput screening (HTS), hit validation, role of medicinal chemistry in drug discovery, computer aided drug design and lead optimization, methods of production of biological drugs), c) non-clinical drug development (animal efficacy and dosing studies, characterization of pharmacokinetic properties of drug molecules (ADME), characterization of mechanisms of action, toxicological screening and safety evaluation, use of animal models of diseases and translational medicine in drug development), d) clinical drug development (first-in-man studies, pharmacodynamic and pharmacokinetic studies in man, clinical phases of drug development, clinical trial design), e) seminars on cases of some historical and contemporary drug discovery and development projects, f) journal club and g) lab work.

Teaching methods

Lectures (62 h), seminars (16 h), journal club-seminars (16 h), lab work (24 h), self study, preparation of presentations and lab report (90 h)

Teaching language

English

Modes of study

Lectures (62 h), seminars (16 h), journal club-seminars (16 h), lab work (24 h), self study, preparation of presentations and lab report (90 h.

Evaluation and evaluation criteria

Numeric 0-5.
Evaluation criteria are based on: a) knowledge of the entire area of the study module, as measured by a written examination (70 % of the grade), b) seminar and journal club presentations and activity (30 % of the grade) and c) accepted report of the lab work.

Recommended year of study

1. year autumn

Study materials

Lecture materials, study materials for seminars and journal clubs, international databanks and guidelines regulating drug development and patent databanks. Relevant reviews and scientific articles.

Recommended reading: B.E. Blass, Basic principles of drug discovery and development, Elsevier ISBN: 978-0-12-411508-8, 574 pages, 2015.

Belongs to following study modules

Institute of Biomedicine
Department of Chemistry
2018–2019
Teaching
Archived Teaching Schedule. Please refer to current Teaching Shedule.
Implementation details are unavailable.
Institute of Biomedicine
DP in Biomedicine
Finnish Study Modules
MDP in Drug Discovery and Development
MDP in Biomedical Imaging
Biomedical Imaging