Uusi opinto-opas (sisältäen myös opetusohjelmat) lukuvuodelle 2018-2019 sijaitsee osoitteessa https://opas.peppi.utu.fi . Tältä sivustolta löytyvät enää vanhat opinto-oppaat ja opetusohjelmat.

The new study guide (incl. teaching schedules) for academic year 2018-2019 can be found at https://studyguide.utu.fi. This site contains only previous years' guides.

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Archived Curricula Guide 2016–2018
Curricula Guide is archieved. Please refer to current Curricula Guides
KEMI6412 Determination of Structure & Activity of Bioactive Compounds 5 ECTS
Organised by
Person in charge
Juha-Pekka Salminen
Preceding studies
Preceding studies: BSc course in Natural Compound Chemistry and MSc course in Chemistry of Tannins and Other Polyphenols are recommended

Learning outcomes

The course teaches students how to use UV, MS, MS/MS, CD and multiple NMR techniques to fully unravel structures of bioactive compounds. At the same time students learn how to determine at least three bioactivity types for the unravelled structure by several bioactivity methods.


The course starts by collecting a large mass of bioactive plant material that is left to macerate in a suitable solvent. After maceration, the extract is freeze-dried and subjected to preparative and semi-preparative HPLC purification steps. Purification is followed by UPLC-DAD. Pure compound is freeze-dried and analysed for UV, MS & MS/MS (Orbitrap), CD, and numerous 1D and 2D NMR spectra. The obtained spectra are inspected in detail to characterize the full structure. The bioactivities will be measured by seven different methods for protein affinity, oxidative activity and antioxidant activity.

Teaching methods

Teaching method Contact Online

Lab practicals

Teaching language


Modes of study

Option 1
Available for:
  • Degree Programme Students
  • Other Students
  • Doctoral Students
  • Exchange Students
  • In English

Final report. No exam.


Numeric 0-5.

Recommended year of study

4. year spring
5. year spring

4th or 5th year, spring 2017, period 3

Course is held every second year. Course can have a maximum of 16 students. Registration 2 weeks before the course in Nettiopsu or by e-mail (j-p.salminen@utu.fi).

Study materials

Material distributed during the course

Belongs to following study modules

Department of Chemistry
Archived Teaching Schedule. Please refer to current Teaching Shedule.
Department of Chemistry
DP in Chemistry
DP in Chemistry
Finnish Study Modules
MDP in Materials Science