BKEM1050 In silico methodologies in biochemistry and molecular medicine 5 ECTS
Organised by
Biochemistry
Person in charge
Pekka Rappu

Learning outcomes

After a successful completion of this course, students will have
1. Obtained an appreciation of the quantitative aspects of analyzing scientific (big) data either stored in large data databases or generated by sophisticated modeling and simulation tools.
2. Gained a basic understanding of applying various bioinformatics methods to large biological data sets.
3. Realized the potential of scientific computing for the study of the behavior of biological systems, in particular large biological macromolecules.

Contents

This course aims at emphasizing the quantitative aspects of scientific research. For this, the course contains three intertwined components: (i) searching and evaluating nucleic acid and protein structural data from various databases, (ii) use of scientific computing to study structural, dynamical, functional and thermodynamical properties of proteins and membranes and their interaction with other molecules, and (iii) using biocomputing tools to access and analyze large and high-throughput data produced and accessible through biochemical and computational experiments.
Students will learn to access biological databases, search and retrieve relevant data, analyze data in a meaningful manner, and link data and results obtained from different tools. A very brief introduction to metabases and data compilation is provided as well. Interaction studies are emphasized through genome-wide mapping of protein-DNA interaction, proteomics-based bioinformatics, and high-throughput mapping of protein-protein interaction networks. Commonly employed modeling and simulation techniques will also be dealt with. These include molecular dynamics, Monte Carlo and Langevin (stochastic, Brownian) dynamics, continuum electrostatics, statistical thermodynamics, protein modeling techniques, protein-ligand docking, protein-ligand affinity calculations and the computer simulation of the protein folding process and enzyme action.

Teaching methods

74 h contact sessions. Lectures and practicals, student tasks, including the presentation of an original article. Attendance to practicals and article presentation are mandatory.

Teaching language

English

Modes of study

Option 1
Available for:
  • Degree Programme Students
  • Other Students
  • Doctoral Students
  • Exchange Students
Participation in classroom work
  • In English

Face to face lectures, explanations during practicals.

Practicals evaluation, article presentation, group discussion, and project report

Evaluation

Pass/fail.

Study materials

Recommended or required reading

Books, articles:

  1. Big data in biomedicine (http://www.nature.com/nature/outlook/big-data/)
  2. Holzinger, A. Biomedical informatics, Springer, Heidelberg, 2014.
  3. PubMed (Publications) (http://www.ncbi.nlm.nih.gov/pubmed/)
  4. Leach, A.R., Molecular modelling. Principles and applications, Second edition, Prentice Hall, New York, 2001
  5. Berendsen, H.J.C Simulating the physical world. Hierarchial modeling from quantum mechanics to fluid dynamics., Cambridge University Press, Cambridge, 2007

Useful databases:

  1. GenBank (DNA) (http://www.ncbi.nlm.nih.gov/nucleotide)
  2. Ensembl and Ensembl Genomes (Genome) (http://www.ensembl.org/ and http://ensemblgenomes.org/)
  3. UniProt (Protein) (http://www.uniprot.org/)
  4. DIP and BioGrid (Protein Interaction) (http://dip.doe-mbi.ucla.edu/dip/Main.cgi and http://thebiogrid.org/)
  5. PDB (protein structure database) (http://www.rcsb.org/)
  6. Entrez (http://www.ncbi.nlm.nih.gov/gquery/gquery.fcgi)

Belongs to following study modules

Department of Biochemistry
Elective advanced studies (Biochemistry)
Department of Biochemistry
Department of Biochemistry

Open enrolments

Oct 25, 2017 - Jan 5, 2018
2016–2017
Teaching
Archived Teaching Schedule. Please refer to current Teaching Shedule.
Department of Biochemistry
DP in Biochemistry
DP Bachelor of Science in Techn. (Biotechnology)
DP in Biochemistry
DP in Food Chemistry
DP on Molecular Biology and Bioenergetics
DP in Biotechnology
Finnish Study Modules